Product References — Pooled Human AB Serum Plasma Derived Heat Inactivated

In the realm of in vitro biological research, ensuring the integrity and consistency of samples is paramount. Serum and plasma, while rich sources of biomolecules, can harbor active enzymes that pose challenges in downstream experiments or assays, impacting the data and results. Heat inactivation presents a well-established technique to address this issue by selectively deactivating these enzymes. The Rationale for Heat Inactivation Enzymes, naturally present within serum and plasma, can introduce unintended enzymatic activity during experimentation. This activity may lead to the degradation of essential components within the sample or trigger unwanted reactions, compromising the validity of results. Heat inactivation...

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:   Expression of Placenta-Specific 1 and its Potential for Eliciting Anti-Tumor Helper T-cell Responses in Head and Neck Squamous Cell Carcinoma Ryusuke Hayashi, Toshihiro Nagato, Takumi Kumai, Kenzo Ohara, Mizuho Ohara, Takayuki Ohkuri, Yui Hirata-Nozaki, Shohei Harabuchi, Akemi Kosaka, Marino Nagata, Yuki Yajima, Syunsuke Yasuda, Kensuke Oikawa, Michihisa Kono, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Esteban Celis, Yasuaki Harabuchi, and Hiroya Kobayashi OncoImmunology December 29, 2020 Various cancers of the head and neck are frequent around the globe, with the most common...

Pooled Human Serum, Heat Inactivated from Innovative Research was used in the following study:   Enhanced Influenza A H1N1 T-Cell Epitope Recognition and Cross-Reactivity to Protein-O-Mannosyltransferase 1 in Pandemrix-Associated Narcolepsy Type 1 A. Vuorela, T. L. Freitag, K. Leskinen, H. Pessa, T. Härkönen, I. Stracenski, T. Kirjavainen, P. Olsen, O. Saarenpää-Heikkilä, J. Ilonen, M. Knip, A. Vaheri, M. Partinen, P. Saavalainen, S. Meri & O. Vaarala Nature Communications April 16, 2021 Narcolepsy type 1 (NT1) is a chronic condition of the brain that causes patients to exhibit excessive daytime drowsiness, cataplexy, and disruption of nocturnal sleep patterns. NT1 is strongly...

Pooled Human AB Serum Off The Clot Heat Inactivated from Innovative Research was used in the following study:   No Evidence of Autoimmunity to Human OX1 or OX2 Orexin Receptors in Pandemrix-Vaccinated Narcoleptic Children Krister Melen, Pinja Jalkanen, Jyrki P. Kukkonen, Markku Partinen, Hanna Nohynek, Arja Vuorela, Outi Vaarala, Tobias L. Freitag, Seppo Meri, Ilkka Julkunen Journal of Translational Autoimmunity May 1, 2020 Narcolepsy is a chronic neurological disorder where diagnoses are divided into two groups; Narcolepsy Type 1 (NT1) is characterized by excessive daytime sleepiness, disturbed sleep at night, and cataplexy. People suffering from NT1 may also experience symptoms...

Pooled Human AB Serum Plasma Derived Heat Inactivated from Innovative Research was used in the following study:   Human Interleukin-4–Treated Regulatory Macrophages Promote Epithelial Wound Healing and Reduce Colitis in Mouse Model Timothy S. Jayme, Gabriella Leung, Arthur Wang, Matthew L. Workentine, Sruthi Rajeev, Adam Shute, Blanca E. Callejas, Nicole Mancini, Paul L. Beck, Remo Panaccione, Derek M. McKay Science Advances June 5, 2020 Murine alternatively activated macrophages can exert anti-inflammatory effects. We sought to determine if IL-4–treated human macrophages [i.e., hM(IL4)] would promote epithelial wound repair and can serve as a cell transfer treatment for inflammatory bowel disease (IBD)....