Assessment of Decellularized Pericardial Extracellular Matrix and Poly(Propylene Fumarate) Biohybrid for Small-Diameter Vascular Graft Applications
Posted by Adam Awdish on
Innovative Grade US Origin Bovine Pericardium from Innovative Research was used in the following study:
Megan Kimicata, Jules D. Allbritton-King, Javier Navarro, Marco Santoro, Takahiro Inoue, Narutoshi Hibino, John P. Fisher
Acta Biomaterialia
April 16, 2020
Each year in the Unites States about 400,000 coronary artery bypass graft surgeries are conducted in treatments for cardiovascular disease (CVD). The current preferred method of coronary artery bypass surgery are autologous grafts, however these procedures are limited by availability and suffer from high failure rates. Further, tissue engineering approaches for use in small diameter vascular grafts fall short due to inappropriate mechanical properties. Bypasses commonly fail due to additional blockages forming, along with irregular performance of vein grafts.
Alternatively, tissue-derived decellularized extracellular matrix (dECM) has comparable characteristics to vessels and are biocompatible, while poly(propylene fumarate) (PPF) has shown promising results for vascular grafts. This study attempted to integrate dECM and PPF to create a biohybrid scaffold (dECM+PPF) suitable for small diameter vascular grafts. One transport study showed diffusion across dECM+PPF without any effect from collagenase. An in vivo study showed re-endothelialization and tissue growth. Overall, the biohybrid presents a viable solution to overcome the limitations of the current treatment methods for CVD.
Related products available from Innovative Research also include:
Innovative Grade US Origin Bovine Heart