BMI1 Enables Extensive Expansion of Functional Erythroblasts from Human Peripheral Blood Mononuclear Cells
Posted by Adam Awdish on
Pooled Human Plasma (Blood Derived) from Innovative Research was used in the following study:
Senquan Liu, Mengyao Wu, Moira Lancelot, Jiusheng Deng, Yongxing Gao, John D. Roback, Tong Chen, and Linzhao Cheng
Molecular Therapy
May 5, 2021
One of the most common treatments for patients with anemia or suffering from major blood loss is a red blood cell (RBC) transfusion from an ABO-matched donor. However, the number of cases that require these transfusions is increasing yearly, creating a growing need for blood donations amid blood shortages at some care facilities with high volumes of patients. Further, the risk of infection or rejection of the donor blood even after it’s been ABO-matched makes transfusion undesirable, and thus researchers have looked for efficient methods of ex vivo RBC creation in the lab for use in treatment.
Unfortunately, it currently remains challenging to develop transferrable RBCs via ex vivo methods, as previous attempts have struggled to produce a desirable amount of such cells in an efficient amount of time. In this study, however, researchers found that the human BMI1 gene causes human erythroblasts to expand at an exponential rate, and in a transferrable state. This knowledge of the BMI1 gene provides a new, easier approach to creating functional erythroblasts in lab settings.
Related products available from Innovative Research also include:
Single Donor Human Peripheral Blood Mononuclear Cells (PBMC) Frozen