Interspecies Comparison of Simultaneous Thrombin and Plasmin Generation
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Pooled Human Plasma (Blood Derived) and Innovative Grade US Origin Rabbit Plasma from Innovative Research was used in the following study:
Interspecies Comparison of Simultaneous Thrombin and Plasmin Generation
Ivan D. Tarandovskiy, Hye Kyung H. Shin, Jin Hyen Baek, Elena Karnaukhova & Paul W. Buehler
Scientific Reports
March 3, 2020
Many fields of basic and pharmaceutical research use animal models of hemostasis and thrombosis and extrapolate the results in humans. However, data from animal models often is not accurate in predicting human responses to various biological factors, and assays provide limited relevant comparisons between human blood and blood of differing animal species.
In this study, researchers performed simultaneous thrombin (TG) and plasmin (PG) generation analysis on blood samples from humans and 6 different species of animals commonly evaluated in pre-clinical research. They observed that TG and PG parameters from baboon and rhesus macaque plasma were close to that of humans, however the other tested species differed both from humans and non-human primates. These findings can provide important insights to future pre-clinical animal species selection.
Related products available from Innovative Research also include:
Innovative Grade US Origin Hamster Armenian Plasma