An inherent T cell deficit in healthy males to C. neoformans infection may begin to explain the sex susceptibility in incidence of cryptococcosis

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:

An inherent T cell deficit in healthy males to C. neoformans infection may begin to explain the sex susceptibility in incidence of cryptococcosis

Tiffany E. Guess, Joseph Rosen, Natalia Castro-Lopez, Floyd L. Wormley Jr, Erin E. McClelland

Biology of Sex Differences
02 September 2019

“…Cryptococcus neoformans is responsible for an estimated 220,000 cases of cryptococcosis, resulting in more than 181,000 deaths each year worldwide. An opportunistic fungal pathogen, C. neoformans typically presents as pneumonia or meningitis, the latter of which is considered an AIDS-defining illness. Interestingly, prevalence of this disease is skewed between males and females. Numerous studies show differences in C. neoformans infection rates, with males having a higher incidence of disease and greater symptom severity in both HIV-positive patients (8M:1F) and HIV-negative patients (2–3M:1F) …10% human serum (50:50 male:female, Innovative Research, Novi, MI) and centrifuged at 400×g to pellet PBMCs…”

Related products available from Innovative Research also include:

• Pooled Human Serum Off The Clot
• Pooled Human Complement Serum
• Pooled Human AB Serum Plasma Derived
• Innovative Grade US Origin Mouse CD1 Plasma