LC-MS/MS analysis of plasma glucosylsphingosine as a biomarker for diagnosis and follow-up monitoring in Gaucher disease in the Spanish population
Posted by Corey Marcath on
Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:
Pilar Irún, Jorge J. Cebolla, Laura López de Frutos, Isabel De Castro-Orós, Mercedes Roca-Espiau and Pilar Giraldo
Clinical Chemistry and Laboratory Medicine (CCLM)
February 3, 2020
The method was validated according to the guidelines of the US Food and Drug administration [33]. Briefly, matrix effects were assessed by analyzing five repetitions of a mixture of IS and ES in methanol and also spiking the same concentrations into pooled normal human plasma (Innovative Research, Novi, MI, USA)…”
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