Product References — Antibodies

In the ever-evolving landscape of molecular biology, precision tools are essential for elucidating complex biological processes. Specifically, when looking at scientific advancement in the field of diagnostic development, the role of specific monoclonal antibodies in understanding and manipulating biological processes cannot be overstated. Innovative Research offers a suite of monoclonal antibodies, including an array of PAI-1 monoclonals, designed to empower researchers in their quest for scientific discovery.   What is PAI-1? Plasminogen Activator Inhibitor-1 (PAI-1) is a protein that functions as the principal inhibitor of tissue plasminogen activator and urokinase plasminogen activator, two enzymes responsible for the conversion of plasminogen...

In the dynamic landscape of medical research, SAR443809 emerges as a promising candidate for the treatment of complement-mediated disorders. Complement-mediated disorders pose a significant challenge in healthcare, marked by the immune system erroneously targeting healthy cells. Central to these disorders is the complement alternative pathway, an integral part of our immune response. When dysregulated, it can precipitate severe and potentially fatal conditions. This groundbreaking study unveils the potential of a humanized IgG4 monoclonal antibody, specifically designed to selectively inhibit the complement alternative pathway, thereby opening new therapeutic avenues for patients globally. Key Insights from Recent Research SAR443809 distinguishes itself with...

Human Factor II (Prothrombin) Purified, Human Fibrinogen Purified, and Rabbit Anti Mouse/Rat Fibrinogen Polyclonal Affinity Purified from Innovative Research were used in the following study:   Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity Alice G. Cheng, Molly McAdow, Hwan K. Kim, Taeok Bae, Dominique M. Missiakas, Olaf Schneewind PLOS Pathogens August 5, 2010 Staphylococcus aureus is a bacterium responsible for many common infections, including bacteremia, pneumonia, soft tissue infections, and septic arthritis among others. There remains no known way to gain protective immunity against S. aureus diseases, and researchers continue to investigate options for an effective vaccine....

Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated HRP Labeled from Innovative Research was used in the following study:   Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib Yusuke Yamashita, Shuhei Morita, Hiroki Hosoi, Hiroshi Kobata, Shohei Kishimoto, Tatsuya Ishibashi, Hiroyuki Mishima, Akira Kinoshita, Bradley J. Backes, Koh-Ichiro Yoshiura, Feroz R. Papa, Takashi Sonoki, and Shinobu Tamura International Journal of Molecular Sciences August 31, 2020 Inositol-requiring enzyme 1α (IRE1α) and protein kinase R-like endoplasmic reticulum kinase (PERK) are key regulators of the unfolded protein response (UPR). The UPR is a cellular mechanism that helps...

Rabbit IgG Affinity Purified from Innovative Research was used in the following study:   Hydrogen sulfide donor NaHS alters antibody structure and function via sulfhydration Zhang Z, Fang X, Yang X, Mitsui T, Huang Y, Mao Z, Huang Y, Takeda M, Yao J. International Immunopharmacology 2019 Jun 4 ”…Hydrogen sulfide (H2S) is an endogenous gaseous mediator, which is produced by many tissues and organs. It has a wide range of physiological functions, including acting as a neurotransmitter, relaxing the blood vessels, regulating blood pressure, scavenging reactive oxygen species and protecting cells against oxidative stress. …Protein Apurified rabbit IgG was obtained...