Biomimetic Anisotropic Polymeric Nanoparticles Coated with Red Blood Cell Membranes for Enhanced Circulation and Toxin Removal
Posted by Adam Awdish on
Innovative Grade US Origin Mouse CD1 Whole Blood from Innovative Research was used in the following study:
Elana Ben-Akiva, Randall A. Meyer, Hongzhe Yu, Jonathan T. Smith, Drew M. Pardoll, Jordan J. Green
Science Advances
April 15, 2020
Therapeutic devices based on biomaterials can have enhanced function due to mimicry of naturally occurring structures. Cell membrane coatings can be used to mimic the functionality of various cell types, enhancing delivery properties, and extending the half-life of blood circulation. However, previous studies have used spherical nanoparticles in their research, thus lacking an important aspect of bio-inspired design.
Particulate shape is a critical factor, as it has been previously shown to affect the drug delivery properties of therapeutics. The creation on future nanobiomaterials requires precise engineering of both physical and chemical properties of the core and surface materials.
The anisotropic shape and membrane coating tested in this study synergize to resist cellular uptake and reduce clearance from the blood, enhancing the detoxification properties of nanoparticles. These nanodevices and their derivatives show promise for a wide range of applications.
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