Human Interleukin-4–Treated Regulatory Macrophages Promote Epithelial Wound Healing and Reduce Colitis in Mouse Model

Pooled Human AB Serum Plasma Derived Heat Inactivated from Innovative Research was used in the following study:

Human Interleukin-4–Treated Regulatory Macrophages Promote Epithelial Wound Healing and Reduce Colitis in Mouse Model

Timothy S. Jayme, Gabriella Leung, Arthur Wang, Matthew L. Workentine, Sruthi Rajeev, Adam Shute, Blanca E. Callejas, Nicole Mancini, Paul L. Beck, Remo Panaccione, Derek M. McKay

Science Advances
June 5, 2020

Murine alternatively activated macrophages can exert anti-inflammatory effects. We sought to determine if IL-4–treated human macrophages [i.e., hM(IL4)] would promote epithelial wound repair and can serve as a cell transfer treatment for inflammatory bowel disease (IBD). RNA sequence analysis revealed statistically significant changes in expression of 996 genes in IL-4–treated macrophages, corroborating the changes in 90 immune-related genes. Consistent with various reports, markers indicative of an alternatively activated M(IL4) were altered, and a panel of genes associated with immune signaling and tissue repair was upregulated. The study used 10% pooled normal human heat-inactivated and sterile-filtered AB Serum purchased from Innovative Research, Inc. in Novi, MI.

Related products available from Innovative Research also include:

Pooled Human AB Serum Off The Clot Heat Inactivated

Pooled Human Complement Serum

Single Donor Human Whole Blood