News — Antigen Abbreviated

Factor IX is one of the proteins that play a role in coagulation. Produced in the liver and activated by Factor XIa or Factor VIIa, depending on whether the coagulation cascade is following the contact activation pathway or the tissue factor pathway, it then catalyzes the next reaction in the cascade continuing down the path toward clot formation. Factor IX deficiency results in Hemophilia B, a clotting disorder that prevents the blood from clotting appropriately. 

Plasminogen Activator Inhibitor 1 (PAI-1) is a key component of fibrinolysis, the process by which the body is able to break apart a cross-linked fibrin clot. As an inhibitor of both tPA and uPA, PAI-1 is the primary inhibitor among the plasminogen activators and plays an important role in allowing appropriate clotting to occur. PAI-1 also plays a role in different conditions and diseases.