Product References — Proteins

tPA from Innovative Research was used in the following study:   Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition James R. Partridge, Rebea M. Choy, Abel Silva-Garcia, Chul Yu, Zhe Li, Hing Sham, Brian Metcalf Journal of Structural Biology 1 March 2019 "...Plasma kallikrein (pKal) is a serine protease responsible for cleaving high molecular-weight kininogen to produce the pro-inflammatory peptide, bradykinin. Unregulated pKal activity can lead to hereditary angioedema (HAE) following excess bradykinin release.tPA from Innovative Research (Novi MI)..."   Related products available from Innovative Research also include: Human Prekallikrein Purified tPA ...

IgG isotype control from Innovative Research was used in the following study:   Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L Chi-Wen Lo, Yury Kryvalap, Tzong-jen Sheu, Ching-Ho Chang, Jan Czyzyk Diabetologia May 2019, Volume 62, Issue 5, pp 822–834 "... We used an in vitro culture system consisting of isolated pancreatic islets, an extract of pancreatic ductal epithelium and a monoclonal antibody (mAb) to serpin B13 or IgG isotype control. ... IgG isotype control (Innovative Research, Novi, MI, USA) were added to the islet cultures...

Human Neutrophil Elastase from Innovative Research was used in the following study:   Neutrophil elastase inhibitory effects of pentacyclic triterpenoids from Eriobotrya japonica (loquat leaves) Jie Zhang, Hao-Yang Xu, Yu-Juan Wu, Xing Zhang, Liu-Qiang Zhang, Yi-Ming Li Journal of Ethnopharmacology Volume 242, 5 October 2019, 111713 "... HNE (EC 3.4.21.37) from purulent human sputum was obtained (Innovative Research Company, Novi, MI, USA). HNE substrate (MeO-Suc-Ala-Ala-Pro-Val-pNA), soybean trypsin inhibitor, LPS, rhodamine 123, verapamil, and dimethyl sulfoxide (DMSO) were also obtained ..."   Related products available from Innovative Research also include: Human Neutrophil Elastase (ELA2) ELISA Kit Porcine Elastase Affinity Purified Lyophilized...

Cellulase from Innovative Research was recently used in the following study: Enzymatic Synthesis, Characterization and Biocompatibility Studies of Cellulose Nanoparticles from Cotton Fibers Prathima Prabhu Tumkur, Tejaswini Ronur Praful, Babu R Lamani, Nicole Nazario Bayn, Krishnan Prabhakaran, Joseph C Hall, and Govindarajan T Ramesh Advances in Nanoscience and Nanotechnology, August 2018 " ... Cotton fibers obtained from Indian farm fields were used as a primary source for the enzymatic synthesize of cellulose nanoparticles. The cotton fibers were separated from cotton linkers and stored. The cellulase enzyme (IRWBE005-20866) used in hydrolysis was purchased from Innovative Research, Inc. (Peary Court Novi, MI)...

Human Receptor Associated Protein (RAP) from Innovative Research was recently used in the following study: Reevaluating the Role of Megalin in Renal Vitamin D Homeostasis Using a Human Cell-Derived Microphysiological System ALTEX preprint, published 08 July 2018 Brian D. Chapron, Alenka Chapron, Brian Phillips, Miracle C. Okoli, Danny D. Shen, Edward J. Kelly, Jonathan Himmelfarb and Kenneth E. Thummel "The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells. We revisited these hypotheses that were previously tested solely in the rodent models, this time using...