Product References — Human Serum

Single Donor Human Whole Blood, Single Donor Human Plasma (Blood Derived), Single Donor Human Complement Serum, Innovative Grade US Origin Porcine Plasma, and Innovative Grade US Origin Porcine Whole Blood from Innovative Research were used in the following study:   Development of a Sensitive Assay to Screen Nanoparticles in vitro for Complement Activation Nuzhat Maisha, Tobias Coombs, and Erin B. Lavik American Chemical Society July 6, 2020 Nanomedicines are often recognized by the innate immune system as a threat, leading to unwanted clearance due to complement activation. This unwanted reaction not only alters the bioavailability of the therapeutic, but can...

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Old World Monkeys are Less than Ideal Transplantation Models for Testing Pig Organs Lacking Three Carbohydrate Antigens (Triple-Knockout) Takayuki Yamamoto, Hayato Iwase, Diyan Patel, Abhijit Jagdale, David Ayares, Douglas Anderson, Devin E. Eckhoff, David K. C. Cooper & Hidetaka Hara Scientific Reports June 17, 2020 Choosing the best nonhuman primate (NHP) model to perform pig-to-NHP xenotransplantation is crucial to determine the feasibility of pig organ transplantation in humans. Triple-knockout (TKO) pigs (with added protective human transgenes) are likely to be optimal sources of organs...

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Analysis of Human Erythropoietin and Erythropoietin N-Linked Glycans Using Capillary Electrophoresis and Mass Spectrometry Jessica M. Risley University of British Columbia June 2020 Proteins with attached sugars can be used to treat illnesses. It is important to study the sugar component of the protein because the sugars are often complex and can cause negative immune system reactions. Glycans are the complex branched oligosaccharides which are covalently linked to protein molecules. Characterization of the glycan component of glycoproteins is challenging due to microheterogeneity, but necessary...

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD Yuki Imura, Makoto Ando, Taisuke Kondo, Minako Ito, and Akihiko Yoshimura JCI Insight July 23, 2020 Tregs suppress excess immunity responses against a variety of antigens, including self-antigens, bacteria–derived antigens, and environmental allergens. Thus, Tregs have been shown to play important roles in suppressing the development of allergies. In humans, some clinical trials of transfer of ex vivo expanded polyclonal Tregs have been performed to suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem...

Single Donor Human Serum Off The Clot from Innovative Research was used in the following study:   An Autoantibody Profile Detects Brugada Syndrome and Identifies Abnormally Expressed Myocardial Proteins Diptendu Chatterjee, Maurizio Pieroni, Meena Fatah, Flavien Charpentier, Kristopher S Cunningham, Danna A Spears, Dipashree Chatterjee, Gonca Suna, J Martjin Bos, Michael J Ackerman, Eric Schulze-Bahr, Sven Dittmann, Pasquale G Notarstefano, Leonardo Bolognese, Firat Duru, Ardan M Saguner, Robert M Hamilton European Heart Journal August 7, 2020 Brugada syndrome (BrS) is characterized by a unique electrocardiogram (ECG) pattern and life-threatening arrhythmias. However, the Type 1 Brugada ECG pattern is often transient,...