Product References — Human Serum

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Reduced Red Blood Cell Surface Level of Factor H as a Mechanism Underlying Paroxysmal Nocturnal Hemoglobinuria Lingjun Zhang, Jin Y. Chen, Cassandra Kerr, Brian A. Cobb, Jaroslaw P. Maciejewski & Feng Lin Leukemia August 19, 2020 Complement is an important factor in the innate immune response that primarily acts to fight infection and clear apoptotic cells. Once activated, the complement cascade helps in the formation of membrane attack complexes (MAC, C5b-9) on the surfaces of pathogens, causing damage and even lysis of the intruding...

Pooled Human AB Serum Off The Clot Heat Inactivated from Innovative Research was used in the following study:   The Safety and Efficacy of Live Viral Vaccines in Patients With Cartilage-Hair Hypoplasia Svetlana Vakkilainen, Iivari Kleino, Jarno Honkanen, Harri Salo, Leena Kainulainen, Michaela Gräsbeck, Eliisa Kekäläinen, Outi Mäkitie, and Paula Klemetti Frontiers in Immunology August 11, 2020 Cartilage-hair hypoplasia (CHH) is a rare skeletal dysplasia with combined immunodeficiency that is caused by genetic mutations. The degree of immunodeficiency experienced by patients with CHH can vary greatly, ranging from asymptomatic lymphopenia to severe deficiencies requiring stem cell transplants. Because of this,...

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T-Cells are Selectively Activated with Amoxicillin-Peptide Adducts Arun Tailor, Xiaoli Meng, Kareena Adair, John Farrell, James C Waddington, Ann Daly, Munir Pirmohamed, Gordon Dear, B Kevin Park, Dean J Naisbitt Toxicological Sciences August 10, 2020 Idiosyncratic drug-induced liver injury (DILI) is a major health concern often associated with a high patient death rate. Amoxicillin-clavulanate is the most common cause of DILI, and the detection of drug-specific CD4+ T-cells in patients with DILI suggests it originates somewhere in the immune system....

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Effect of Intravenous Immunoglobulin (IVIg) on Primate Complement-Dependent Cytotoxicity of Genetically Engineered Pig Cells: Relevance to Clinical Xenotransplantation Takayuki Yamamoto, Yehua Cui, Diyan Patel, Abhijit Jagdale, Hayato Iwase, David Ayares, David K. C. Cooper & Hidetaka Hara Scientific Reports July 16, 2020 Triple-knockout (TKO) pigs are thought to be ideal sources of organs for clinical xenotransplantation because many humans have no preformed antibody to TKO pig cells. Pig kidney or heart graft survival in nonhuman primates (NHPs) now extends to many months, or in...

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:   Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles Hyungtaek Jeon, Su-Kyung Kang, Myung-Shin Lee PLoS ONE July 7, 2020 Extracellular vesicles (EVs) are nano-sized membrane vesicles (20–500 nm) of endocytic origin that are secreted by most cells under normal physiological conditions, as well as by cells undergoing pathological processes. EVs contain a variety of molecules such as proteins, nucleic acids, and lipids, which are affected by environmental factors and health conditions, making them potential biomarkers for diseases...